Endocrine Abstracts

Neuropathy and ischemia play paramount roles in the pathogenesis of diabetic vascular complications. Reduced tissue blood flow in experimental diabetic complications can be corrected by several disease-modifying drugs. Actovegin (deproteinised hemoderivative product) is considered to be a potential agent to stimulate cellular energy metabolism and improve cell function. Testosterone vascular effects can be mediated via increasing cardiac and muscle activity and endothelium dep...

Aim: To investigate the association between presence of sarcopenia and type 2 diabetes mellitus (T2DM).Methods: The study included 76 women over 60 years old (Me72[67;77] years). Patients were examined with evaluation of muscle mass, muscle strength and muscle function. Skeletal muscle mass index (SMMI) was evaluated with bioimpedance testing. Sarcopenia was defined as a SMMI ≤6,75 kg/m2. Peripheral neuropathy was studied with calculatio...

The efficacy and safety of saxagliptin – a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme – was investigated in two double-blind, randomised trials (CV181-014/Study 1 and CV181-039/Study 2), either as add-on therapy in patients with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin alone (HbA1c 7.0–10.0%) or as initial combination therapy with metformin i...